Principal to the House Collection is the Music Room, which was designed in 1927 by Lawrence Grant White of the New York City architectural firm of McKim, Mead & White. In the Music Room are displays of tapestries, sculptures, paintings, and furniture dating from the fifteenth to the eighteenth centuries. Also in the room is a 1926 Steinway concert grand piano signed by Ignacy Paderewski, who had played this instrument many times in the home of Mildred Bliss's mother in Santa Barbara, California.
Of particular importance in the House Collection are several masterpieces including the Flemish tapestry The Prince of Malice (ca. 1470–80), Tilman Riemenschneider's early sixteenth-century lindenwood sculpture Virgin and Child on the Crescent Moon, and El Greco's early seventeenth-century Visitation.